smallpox had affected the human population for three millennia, infecting the young, the old, the rich, the poor, the weak and the resilient.
Spread by a cough or sneeze, smallpox caused deadly rashes, lesions, high fevers and painful headaches – and killed up to 30% of its victims, while leaving some of its survivors blind or disfigured.
An estimated 300 million people died from smallpox in the 20th century alone, and more than half a million died every year before the launch of the global eradication programme.
http://polioeradication.org/news-post/the-world-without-vaccines/_- Steve
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