The question of how the communication systems of neurons, namely their neurotransmitter systems, first evolved has now also been largely answered. In a recent sweeping review for Current Biology, Detlev Arendt of Heidelberg, Germany, details the full genesis of the actual hardware of both the pre- and postsynapse. The paper lays down the order in which the canonical small molecule transmitter systems of life sequentially made their first appearance on the stage, and chronicles the novel deployment and proliferation of the associated structural matrix, scaffolding and adhesion molecules that made it all happen.
https://phys.org/news/2020-06-evolution-synapse.html
_- Steve
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